Risk factors for developing end-stage renal failure in diabetes have been identified

The risk of developing end-stage renal failure was higher among patients with diabetes who had increased systolic and diastolic blood pressure at a young age. The highest risk is in patients under 40 years of age who have not received antihypertensive drugs.

Scientists Chonnam National University and Soongsil University analyzed the effect of hypertension in patients with diabetes on the development of end-stage renal failure. The results of the study were published in the journal Hypertension.

The incidence of end-stage renal failure depended on age and the degree of increase in systolic and diastolic blood pressure. The highest risk was found in patients under 40 years of age, in whom diastolic pressure increased to 110 mmHg. Art. and higher (risk ratio (RR) was 4.5). When diastolic pressure increases to 110 mm Hg. Art. and higher in patients over 70 years of age, the likelihood of developing end-stage renal failure was lower (RR = 2.3).

Additional analyzes adjusted for sex, age, antihypertensive therapy, and history of chronic kidney disease found that the likelihood of developing end-stage renal disease was higher among men younger than 40 years of age who were not receiving antihypertensive medications and with a history of chronic kidney disease.

Thus, the likelihood of developing the disease among men under 40 years of age whose systolic blood pressure increased to 160 mm Hg. Art. and more, turned out to be significantly higher than in women of a similar age (risk ratio was 3.36 and 2.01, respectively). However, among people over 40 years of age, patient gender did not have a significant effect.

The researchers analyzed the Korean National Health Screening Program database and identified 2,563,870 patients with diabetes over 20 years of age. Participants were divided into groups depending on age and blood pressure levels. The average follow-up time was 7.15 years.

End-stage renal disease was indicated by the need for hemodialysis, peritoneal dialysis, or renal transplantation. During follow-up, end-stage renal disease was diagnosed in 26,580 participants (1.04%).

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