Researchers from the University of Iowa identified groups of antihypertensive drugs that had a protective effect on the development of rosacea.. About it reports MDedge Dermatology with reference to Journal of the American Academy of Dermatology.
The study included 680 patients with hypertension who received thiazide diuretics (127 people) or angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers and calcium channel blockers (553 people) for five years.
Taking antihypertensive drugs protected against the development of rosacea, with the exception of thiazide diuretics. The relative risk for ACE inhibitors was 0.50, angiotensin II receptor blockers – 0.69, beta blockers – 0.55, calcium channel blockers – 0.39 compared with thiazides.
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Researchers observed such dependencies in white women aged 50 years and older, but they were absent in the dark-skinned group.
The scientists’ initial hypothesis was the opposite: that antihypertensive drugs might contribute to the progression of rosacea. But according to lead researcher Dr. Jennifer Powers the exact opposite effect was found. According to the study authors, the positive dynamics are associated with a decrease in peripheral vascular damage, and therefore with a decrease in the risk of rosacea when taking antihypertensive drugs.
Rosacea is an inflammatory skin disease characterized by redness and the appearance of blood vessels and papules on the face that are visible to the naked eye. It is more often diagnosed in older people with fair skin. The mechanism of development is not fully understood, but progressive damage to the vascular endothelium plays a role, causing inflammation and a pathological variant of the new vasculature.