The study shows that men may develop characteristic symptoms of PCOS, a common reproductive disorder that, by definition, only affects women. Dr. spoke about this Jia Zhu from Boston Children’s Hospital to the Healio portal.
“By taking the genetic factors that contribute to the risk of PCOS in women and examining them in men, we found that these genetic risk factors are associated with an increased risk of obesity, type 2 diabetes, cardiovascular disease and male pattern baldness. Thus, some of the mechanisms that lead to the manifestations of PCOS do not act directly through the ovaries, but rather through pathways that are present in women and men,” she explained.
The researchers analyzed data from the UK Biobank of over 176,000 men who assessed the relationship between genetic risk levels and cardiometabolic outcomes. As risk scores increased, the researchers observed increases in body mass index, glycated hemoglobin (HbA1c) and triglyceride levels, and the risk of obesity, diabetes, and cardiovascular disease. At the same time, the levels of high-density lipoproteins, on the contrary, decreased.
In addition, as genetic risks increased, the free androgen index increased and sex hormone binding globulin levels decreased.
The name PCOS suggests that the ovaries play a central role in the disease, although it is not always a disease of the primarily female reproductive system, Dr. Zhu explained. She believes that metabolic disease may also manifest itself in men who carry genetic risk factors for PCOS. VLI