Scientists have identified age and impaired kidney function as the main factors that increase the risk of developing diabetic foot. However, glycemic control did not reduce the likelihood of these changes and did not affect the progression of peripheral artery disease.
Scientists from Fudan University and Macau University of Science and Technology described the prevalence and factors that increase the likelihood of developing diabetic foot in high-risk diabetic patients, as well as the detection rate and factors that increase the risk of peripheral artery disease. The study results were published in the journal Diabetes Research and Clinical Practice.
An increased risk of developing diabetic foot disease was observed in 27.8% of patients with diabetes mellitus. Age and increasing urinary albumin/creatinine ratio increased the likelihood of developing diabetic foot, while increasing estimated glomerular filtration rate decreased it.
The prevalence of peripheral artery disease was 11.1% among participants with diabetes. Independent risk factors for peripheral artery disease include age, heart rate, and low-density lipoprotein levels. Independent factors that protected against the development of the disease were the level of high-density lipoproteins, a high estimated glomerular filtration rate and the ratio of lymphocytes to monocytes. Interestingly, glycated hemoglobin levels did not increase the likelihood of developing diabetic foot or progression of peripheral artery disease.
The study was conducted on 3,030 diabetic patients as part of a foot screening program in Shanghai from March to April 2021. The average age of the participants was 70.3 years.