Metformin reduced the risk of developing open-angle glaucoma » Medvestnik


Taking metformin reduces the risk of developing open-angle glaucoma, and other antidiabetic drugs (insulin, sulfonylurea derivatives) reduce the risk of age-related macular degeneration, a study by scientists from the Erasmus University Medical Center in Rotterdam showed. The results were published in the journal JAMA Ophthalmology.

Untreated type 2 diabetes was associated with an increased risk of open-angle glaucoma (hazard ratio (RR) 1.5), age-related macular degeneration (RR = 1.35) and cataracts (RR = 1.63).

The likelihood of developing open-angle glaucoma decreased significantly when taking metformin (RR = 0.18). The analysis showed that the cumulative lifetime risk of developing the disease while taking metformin was lower even in comparison with study participants without type 2 diabetes (1.5 and 7.2%, respectively).

Taking other diabetes medications (insulin, sulfonylureas) reduced the likelihood of age-related macular degeneration (RR = 0.32). The lifetime risk of age-related macular degeneration during therapy was also lower than in people without type 2 diabetes (17 and 33.1%, respectively).

The effect of antidiabetic drugs on the risk of developing cataracts could not be determined.

The researchers analyzed data from a Rotterdam study of 11,260 patients, which tracked the incidence of open-angle glaucoma, age-related macular degeneration and cataracts among participants. The average age of the participants was 65.1 years.

During the study, type 2 diabetes was detected in 2,406 people. Open-angle glaucoma was diagnosed in 324 patients, age-related macular degeneration – in 1935 cases. Cataracts were detected in 4203 participants.



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